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Article

[Analysis of genetic determinants of multidrug and extensively drug-resistant Mycobacterium tuberculosis using oligonucleotide microchip].

Molekuliarnaia biologiia - 1 Jan 2000

Zimenkov D V, Kulagina E V, Antonova O V, Surzhikov S A, Bespiatykh Iu A, Shitikov E A, Il'ina E N, Mikhaĭlovich V M, Zasedatelev A S, Griadunov D A

Abstract excerpt

Steadily growing resistance of the tuberculosis causative agent towards a broad spectrum of anti-tuberculosis drugs calls for rapid and reliable methods for identifying the genetic determinants responsible for this resistance. In this study, we present a biochip-based method for simultaneous identification of mutations within rpoB gene associated with rifampin resistance, mutations in katG, inhA, ahpC genes...

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PMID: 25850294

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