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Article

Genetic selection for mutations that impair the co-operative binding of lambda repressor.

Molecular microbiology - 1 Feb 1994

Benson N, Adams C, Youderian P

Abstract excerpt

Bacteriophage lambda repressor binds co-operatively to adjacent pairs of DNA target sites. A novel combination of positive genetic selections, involving two different operon fusions derived from P22 challenge phages, was used to isolate mutant lambda repressors that have lost the ability to bind co-operatively to tandem sites yet retain the ability to bind a strong, single site. These cb (co-operative binding)...

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Identifiers

PMID: 8152379
DOI: 10.1111/j.1365-2958.1994.tb00337.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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