Article
Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes.
American journal of hypertension - 1 May 2004
Kamide Kei, Takiuchi Shin, Tanaka Chihiro, Miwa Yoshikazu, Yoshii Masayoshi, Horio Takeshi, Mannami Toshifumi, Kokubo Yoshihiro, Tomoike Hitonobu, Kawano Yuhei, Miyata Toshiyuki
Abstract excerpt
BACKGROUND: Mutations in serine-threonine kinase WNK4 with no lysine (K) at a key catalytic residue cause familial hypertension known as pseudohypoaldosteronism type II (PHAII). The objective of this study was to test whether more subtle changes of WNK4 could be implicated in hypertension or renal failure. METHODS: We screened 956 Japanese patients with hypertension or renal failure for mutations in exons 7 and...
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