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Article

Change of tropism of SL3-2 murine leukemia virus, using random mutational libraries.

Journal of virology - 1 Sept 2004

Bahrami Shervin, Duch Mogens, Pedersen Finn Skou

Abstract excerpt

SL3-2 is a polytropic murine leukemia virus with a limited species tropism. We cloned the envelope gene of this virus, inserted it into a bicistronic vector, and found that the envelope protein differs from other, similar envelope proteins that also utilize the polytropic receptor (Xpr1) in that it is severely impaired in mediating infection of human and mink cells. We found that two adjacent amino acid mutations...

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Identifiers

PMID: 15308729
DOI: 10.1128/JVI.78.17.9343-9351.2004
PMCID: PMC506969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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