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Article

Expanded host cell tropism and cytopathic properties of feline immunodeficiency virus strain PPR subsequent to passage through interleukin-2-independent T cells.

Journal of virology - 1 Feb 2000

Lerner D L, Elder J H

Abstract excerpt

A cytopathic variant of feline immunodeficiency virus (FIV) strain PPR emerged after passage of wild-type virus on an interleukin-2-independent cell line. The virus, termed FIV-PPRglial, displayed a phenotype markedly different from the parental virus, including the ability to productively infect previously refractory cell lines, induction of large syncytia, and accelerated kinetic properties. A chimeric...

Topics

Amino Acid Sequence
Animals
Cats
Cell Line
Chemokine CCL4
Chemokine CCL5
Cytopathogenic Effect, Viral
Giant Cells
Immunodeficiency Virus, Feline
Interleukin-2
Macrophage Inflammatory Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

T-Lymphocytes

Transfection

Tropism

Source

Open in PubMed Open full text

Identifiers

PMID: 10644358
DOI: 10.1128/jvi.74.4.1854-1863.2000
PMCID: PMC111663

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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