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Article

Second site mutation in the virus envelope expands the host range of a cytopathic variant of Moloney murine leukemia virus.

Virology - 10 Nov 2012

Ferrarone John, Knoper Ryan C, Li Randolph, Kozak Christine A

Abstract excerpt

Spl574 MLV (murine leukemia virus) is a variant of Moloney ecotropic MLV (MoMLV) that is cytopathic in Mus dunni cells and restricted by other mouse cells. Its host range and cytopathicity are due to a mutation, S82F, at a site critical for binding to the CAT-1 receptor. To identify residues that affect affinity for receptor variants, virus with S82F was passed in restrictive cells. The env genes of the adapted...

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Identifiers

PMID: 22835818
DOI: 10.1016/j.virol.2012.06.031
PMCID: PMC3444676

Genes

CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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