Article
Identification of a retroviral receptor used by an envelope protein derived by peptide library screening.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jun 2007
Sarangi Anindita, Bupp Keith, Roth Monica J
Abstract excerpt
This study demonstrates the power of a genetic selection to identify a variant virus that uses a new retroviral receptor protein. We screened a random peptide library within the receptor-binding domain of a feline leukemia virus retroviral Envelope (FeLV Env) protein for productive infection of feline AH927 cells. One variant, A5, obtained with altered tropic properties acquired the ability to use the solute...
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