Article
Role of variable regions A and B in receptor binding domain of amphotropic murine leukemia virus envelope protein.
Journal of virology - 1 Nov 1998
Han J Y, Zhao Y, Anderson W F, Cannon P M
Abstract excerpt
For the amphotropic murine leukemia virus (MuLV), a 208-amino-acid amino-terminal fragment of the surface unit (SU) of the envelope glycoprotein is sufficient to bind to its receptor, Pit2. Within this binding domain, two hypervariable regions, VRA and VRB, have been proposed to be important for receptor recognition. In order to specifically locate residues that are important for the interaction with Pit2, we...
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