Article
Role of variable regions A and B in receptor binding domain of amphotropic murine leukemia virus envelope protein.
Journal of virology - 1 Nov 1998
Han J Y, Zhao Y, Anderson W F, Cannon P M
Abstract excerpt
For the amphotropic murine leukemia virus (MuLV), a 208-amino-acid amino-terminal fragment of the surface unit (SU) of the envelope glycoprotein is sufficient to bind to its receptor, Pit2. Within this binding domain, two hypervariable regions, VRA and VRB, have been proposed to be important for...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Binding Sites
- Cell Line
- Genetic Variation
- Leukemia Virus, Murine
- Mice
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Binding
- Protein Conformation
- Protein Processing, Post-Translational
- Receptors, Virus
- Recombinant Fusion Proteins
- Sequence Homology, Amino Acid