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Article

Muscle mechano growth factor is preferentially induced by growth hormone in growth hormone-deficient lit/lit mice.

The Journal of physiology - 15 Oct 2004

Iida Keiji, Itoh Emina, Kim Dong-Sun, del Rincon Juan P, Coschigano Karen T, Kopchick John J, Thorner Michael O

Abstract excerpt

Two muscle insulin-like growth factor-I (IGF-I) mRNA splice variants (IGF-IEa and IGF-IEb) have been identified in rodents. IGF-IEb, also called mechano growth factor (MGF) has been found to be upregulated by exercise or muscle damage. Growth hormone (GH) is the principal regulator of IGF-I expression in several tissues including skeletal muscle. Therefore, we investigated the effect of chronic GH excess or...

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Source

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Identifiers

PMID: 15308683
DOI: 10.1113/jphysiol.2004.069500
PMCID: PMC1665252

Genes

GHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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