Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic correction of dwarfism by constitutive expression of growth hormone.

Endocrinology - 1 Nov 1996

Hahn T M, Copeland K C, Woo S L

Abstract excerpt

GH is normally secreted in a pulsatile fashion. When GH is deficient, dwarfism is the result in both rodents and humans. An adenoviral vector containing the rat GH complementary DNA was used to induce constitutive GH expression in hepatocytes of GH-deficient lit/lit mice. Elevated serum GH increased circulating insulin-like growth factor I concentrations, corrected the growth deficiency, and normalized body...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Weight
Share to DNA, Complementary
Share to Genetic Vectors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Mutant Strains

Share to Phenotype

Source

Identifiers

PMID: 8895372
DOI: 10.1210/endo.137.11.8895372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic correction of dwarfism by constitutive expression of growth hormone.PMID 8895372Read ↗

Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH‐releasing factor neurons.Semantic proximity Read ↗

Long-term regulated expression of growth hormone in mice after intramuscular gene transferSemantic proximity Read ↗

Minireview: Mechanisms of Growth Hormone-Mediated Gene RegulationSemantic proximity Read ↗

Acute control of insulin-like growth factor-I gene transcription by growth hormone through Stat5b.Semantic proximity Read ↗

Liver-specific Deletion of the Growth Hormone Receptor Reveals Essential Role of Growth Hormone Signaling in Hepatic Lipid MetabolismSemantic proximity Read ↗

A Mouse with Targeted Ablation of the Growth Hormone-Releasing Hormone Gene: A New Model of Isolated Growth Hormone DeficiencySemantic proximity Read ↗

Partial correction of murine hereditary growth disorder by germ-line incorporation of a new gene.Semantic proximity Read ↗

Growth hormone abolishes beneficial effects of calorie restriction in long-lived Ames dwarf mice.Semantic proximity Read ↗

Muscle mechano growth factor is preferentially induced by growth hormone in growth hormone-deficient lit/lit mice.Semantic proximity Read ↗

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expressionSemantic proximity Read ↗

Pulsatility of growth hormone (GH) signalling in liver cells: role of the JAK-STAT5b pathway in GH action.Semantic proximity Read ↗

Long-term human growth hormone expression and partial phenotypic correction by plasmid-based gene therapy in an animal model of isolated growth hormone deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.