Phenotypic correction of dwarfism by constitutive expression of growth hormone.

doi:10.1210/endo.137.11.8895372

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Article

Phenotypic correction of dwarfism by constitutive expression of growth hormone.

Endocrinology - 1 Nov 1996

Hahn T M, Copeland K C, Woo S L

Abstract excerpt

GH is normally secreted in a pulsatile fashion. When GH is deficient, dwarfism is the result in both rodents and humans. An adenoviral vector containing the rat GH complementary DNA was used to induce constitutive GH expression in hepatocytes of GH-deficient lit/lit mice. Elevated serum GH increa...

Topics

Adenoviruses, Human
Animals
Body Composition
Body Weight
DNA, Complementary
Dwarfism
Genetic Therapy
Genetic Vectors
Growth Hormone
Humans
Insulin-Like Growth Factor I
Liver
Mice
Mice, Mutant Strains
Organ Size
Phenotype
Rats
alpha 1-Antitrypsin

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