Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of IGF-I in skeletal muscle of transgenic mice does not prevent unloading-induced atrophy

1 Sept 1998

Abstract excerpt

This study examined the association between local insulin-like growth factor I (IGF-I) overexpression and atrophy in skeletal muscle. We hypothesized that endogenous skeletal muscle IGF-I mRNA expression would decrease with hindlimb unloading (HU) in mice, and that transgenic mice overexpressing human IGF-I (hIGF-I) specifically in skeletal muscle would exhibit less atrophy after HU. Male transgenic mice and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Growth Hormone and Insulin-like Growth Factors
Share to Muscle Physiology and Disorders
Share to Neurogenetic and Muscular Disorders Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9725801
DOI: 10.1152/ajpendo.1998.275.3.e373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of IGF-I in skeletal muscle of transgenic mice does not prevent unloading-induced atrophyPMID 9725801Read ↗

Balanced Diet-Fed Fat-1 Transgenic Mice Exhibit Lower Hindlimb Suspension-Induced Soleus Muscle Atrophy.Semantic proximity Read ↗

Muscle mechano growth factor is preferentially induced by growth hormone in growth hormone-deficient lit/lit mice.Semantic proximity Read ↗

Skeletal muscle growth defect in human growth hormone transgenic rat is accompanied by phenotypic changes in progenitor cells.Semantic proximity Read ↗

Targeted Expression of IGF‐1 Transgene to Skeletal Muscle Accelerates Muscle and Motor Neuron RegenerationSemantic proximity Read ↗

H19X‐encoded miR‐322(424)/miR‐503 regulates muscle mass by targeting translation initiation factorsSemantic proximity Read ↗

Incorporation of a skeletal muscle-specific enhancer in the regulatory region of Igf1 upregulates IGF1 expression and induces skeletal muscle hypertrophy.Semantic proximity Read ↗

miR-378 attenuates muscle regeneration by delaying satellite cell activation and differentiation in miceSemantic proximity Read ↗

Transgenic mouse models for studying the functions of insulin-like growth factor-binding proteins.Semantic proximity Read ↗

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expressionSemantic proximity Read ↗

Sex-Specific Control of Muscle Mass: Elevated IGFBP Proteolysis and Reductions of IGF-1 Levels Are Associated with Substantial Loss of Carcass Weight in Male DU6PxIGFBP-2 Transgenic Mice.Semantic proximity Read ↗

Homer 2 antagonizes protein degradation in slow-twitch skeletal muscles.Semantic proximity Read ↗

Liver-Specific Expression of Human Insulin-Like Growth Factor Binding Protein-1 in Transgenic Mice: Repercussions on Reproduction, Ante- and Perinatal Mortality and Postnatal Growth<sup>1</sup>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.