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Article

CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73.

The Journal of biological chemistry - 29 Oct 2004

Demma Mark J, Wong Serena, Maxwell Eugene, Dasmahapatra Bimalendu

Abstract excerpt

The p53 protein plays a major role in the maintenance of genome stability in mammalian cells. Mutations of p53 occur in over 50% of all cancers and are indicative of highly aggressive cancers that are hard to treat. Recently, there has been a high degree of interest in therapeutic approaches to restore growth suppression functions to mutant p53. Several compounds have been reported to restore wild type function...

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Identifiers

PMID: 15308639
DOI: 10.1074/jbc.M401854200

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PRIMA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73.PMID 15308639Read ↗

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The Mutant p53-Conformation Modifying Drug, CP-31398, Can Induce ApoptosisSemantic proximity Read ↗

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