Article
Rescue of mutant p53 transcription function by ellipticine.
Oncogene - 17 Jul 2003
Peng Yanhua, Li Changgong, Chen Lihong, Sebti Said, Chen Jiandong
Abstract excerpt
The p53 tumor suppressor is frequently inactivated in tumors by point mutations in the DNA-binding domain, resulting in loss of sequence-specific DNA binding and transcription function. We present evidence that ellipticine can restore the transactivation function of several transfected p53 mutants (175 H, 248W, 249S, 273 H, 281G), resulting in the induction of p53-responsive genes (p21(WAF1),MDM2) and activation...
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