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Article

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

Oncogene - 28 Mar 2002

Rippin Thomas M, Bykov Vladimir J N, Freund Stefan M V, Selivanova Galina, Wiman Klas G, Fersht Alan R

Abstract excerpt

The Pfizer compound CP-31398 has been reported to stabilize the core domain of the tumour suppressor p53 in vitro and be an effective anti-cancer drug by virtue of rescuing destabilized mutants of p53. We did not detect any interaction between the p53 core domain and CP-31398 in vitro by a wide range of quantitative biophysical techniques over a wide range of conditions. CP-31398 did not stabilize p53 in our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11948395
DOI: 10.1038/sj.onc.1205362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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