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Article

Restoration of p53 to limit tumor growth.

Current opinion in oncology - 1 Jan 2008

Wang Wenge, El-Deiry Wafik S

Abstract excerpt

PURPOSE OF REVIEW: p53 mutation occurs in over half of all human tumors. Among the remaining tumors, although they may process a wild-type p53, the pathways of p53-induced cell-cycle arrest and apoptosis are deficient. Therefore, p53 serves as a unique molecular target for cancer therapy. This review focuses on the current progress regarding restoration of p53 function in human tumors for molecularly targeted...

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Source

Identifiers

PMID: 18043262
DOI: 10.1097/CCO.0b013e3282f31d6f

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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