Article
The gate controlling cell wall synthesis in Staphylococcus aureus.
Molecular microbiology - 1 Aug 2004
Komatsuzawa Hitoshi, Fujiwara Tamaki, Nishi Hiromi, Yamada Sakuo, Ohara Masaru, McCallum Nadine, Berger-Bächi Brigitte, Sugai Motoyuki
Abstract excerpt
Glucosamine-6-P occupies a central position between cell wall synthesis and glycolysis. In the initial steps leading to peptidoglycan precursor formation glucosamine-6-P is processed sequentially to UDP-N-acetylglucosamine, while to enter the glycolysis pathway, glucosamine-6-P is isomerized by NagB to fructose-6-P. Although we could not demonstrate NagB activity, nagB inactivation significantly reduced growth....
Topics
- Acetylglucosamine
- Aldose-Ketose Isomerases
- Bacterial Proteins
- Cell Wall
- Culture Media
- Gene Expression Regulation, Bacterial
- Glucosamine
- Glucose
- Glucose-6-Phosphate
- Humans
- Methicillin Resistance