Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Living with an imperfect cell wall: compensation of femAB inactivation in Staphylococcus aureus.

BMC genomics - 4 Sept 2007

Hübscher Judith, Jansen Andrea, Kotte Oliver, Schäfer Juliane, Majcherczyk Paul A, Harris Llinos G, Bierbaum Gabriele, Heinemann Matthias, Berger-Bächi Brigitte

Abstract excerpt

BACKGROUND: Synthesis of the Staphylococcus aureus peptidoglycan pentaglycine interpeptide bridge is catalyzed by the nonribosomal peptidyl transferases FemX, FemA and FemB. Inactivation of the femAB operon reduces the interpeptide to a monoglycine, leading to a poorly crosslinked peptidoglycan. femAB mutants show a reduced growth rate and are hypersusceptible to virtually all antibiotics, including methicillin,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Wall
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Complementation Test

Share to Oligonucleotide Array Sequence Analysis

Share to Operon

Share to Polysaccharides

Share to Staphylococcus aureus

Share to Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 17784943
DOI: 10.1186/1471-2164-8-307
PMCID: PMC2045680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Living with an imperfect cell wall: compensation of femAB inactivation in Staphylococcus aureus.PMID 17784943Read ↗

Cell wall monoglycine cross-bridges and methicillin hypersusceptibility in a femAB null mutant of methicillin-resistant Staphylococcus aureus.Semantic proximity Read ↗

The Secondary Resistome of Methicillin-Resistant Staphylococcus aureus to β-Lactam AntibioticsSemantic proximity Read ↗

Restriction of Arginine Induces Antibiotic Tolerance in <i>Staphylococcus aureus</i>Semantic proximity Read ↗

Increased overall antibiotic susceptibility in Staphylococcus aureus femAB null mutants.Semantic proximity Read ↗

A PBP 2 mutant devoid of the transpeptidase domain abolishes spermine-β-lactam synergy in Staphylococcus aureus Mu50.Semantic proximity Read ↗

The essential <i>Staphylococcus aureus</i> gene <i>fmhB</i> is involved in the first step of peptidoglycan pentaglycine interpeptide formationSemantic proximity Read ↗

Characterization of peptidoglycan in fem-deletion mutants of methicillin-resistant Staphylococcus aureus by solid-state NMR.Semantic proximity Read ↗

Role of the msaABCR Operon in Cell Wall Biosynthesis, Autolysis, Integrity, and Antibiotic Resistance in Staphylococcus aureusSemantic proximity Read ↗

The oxidative stress regulator, PerR, is required for staphyloferrin B-mediated iron acquisition in Staphylococcus aureus.Semantic proximity Read ↗

Impact of the accessory gene regulatory system (Agr) on extracellular proteins, codY expression and amino acid metabolism in Staphylococcus epidermidis.Semantic proximity Read ↗

Guanine Limitation Results in CodY-Dependent and -Independent Alteration of Staphylococcus aureus Physiology and Gene Expression.Semantic proximity Read ↗

NsaRS is a cell-envelope-stress-sensing two-component system of Staphylococcus aureusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.