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Article

GlmS and NagB regulate amino sugar metabolism in opposing directions and affect Streptococcus mutans virulence.

PloS one - 1 Jan 2012

Kawada-Matsuo Miki, Mazda Yusuke, Oogai Yuichi, Kajiya Mikihito, Kawai Toshihisa, Yamada Sakuo, Miyawaki Shouichi, Oho Takahiko, Komatsuzawa Hitoshi

Abstract excerpt

Streptococcus mutans is a cariogenic pathogen that produces an extracellular polysaccharide (glucan) from dietary sugars, which allows it to establish a reproductive niche and secrete acids that degrade tooth enamel. While two enzymes (GlmS and NagB) are known to be key factors affecting the entrance of amino sugars into glycolysis and cell wall synthesis in several other bacteria, their roles in S. mutans remain...

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Identifiers

PMID: 22438919
DOI: 10.1371/journal.pone.0033382
PMCID: PMC3306399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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