The haplotype runs test: the parent-parent-affected offspring trio design.

Abstract excerpt

The increasing availability of maps of dense polymorphic markers makes use of haplotype data in family-based association analyses an attractive alternative to single marker association tests. We describe a novel class of statistics designed to test for an association between marker haplotypes and a qualitative trait using the parent-parent-affected-offspring trio design. Our haplotype runs test (HRT) is based on...

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