Article
Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia.
Neuroreport - 26 Aug 2004
Bah J, Quach H, Ebstein R P, Segman R H, Melke J, Jamain S, Rietschel M, Modai I, Kanas K, Karni O, Lerer B, Gourion D, Krebs M O, Etain B, Schürhoff F, Szöke A, Leboyer M, Bourgeron T
Abstract excerpt
Schizophrenia is characterized by thought disorders, hallucinations and delusions. Genetic studies have shown a high linkage at chromosome 6q16-21. Among the genes located in this region is the glutamate receptor ionotropic kainate 2 gene (GRIK2 or GLUR6), a functional candidate for susceptibility to schizophrenia. In this study, transmission of GRIK2 was evaluated in 356 schizophrenic patients from three...
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