Article
Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2003
Makino Chieko, Fujii Yo, Kikuta Rumiko, Hirata Naotsugu, Tani Ayako, Shibata Atsushi, Ninomiya Hideaki, Tashiro Nobutada, Shibata Hiroki, Fukumaki Yasuyuki
Abstract excerpt
The glutamatergic dysfunction hypothesis suggests that genes involved in the glutamate neurotransmitter system are candidates for schizophrenia-susceptibility genes. We have been conducting systematic studies of the association between glutamate receptors and schizophrenia. We report on a positive association of some haplotypes of the AMPA receptor subunit GluR4 gene (GRIA4) with schizophrenia. We genotyped 100...
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