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Article

The Kaposi's sarcoma-associated herpesvirus complement control protein mimics human molecular mechanisms for inhibition of the complement system.

The Journal of biological chemistry - 22 Oct 2004

Mark Linda, Lee Wen H, Spiller O Brad, Proctor David, Blackbourn David J, Villoutreix Bruno O, Blom Anna M

Abstract excerpt

Kaposi's sarcoma-associated human herpesvirus (KSHV) is thought to cause Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Previously, we reported that the KSHV complement control protein (KCP) encoded within the viral genome is a potent regulator of the complement system; it acts both as a cofactor for factor I and accelerates decay of the C3 convertases (Spiller, O. B.,...

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Source

Identifiers

PMID: 15304516
DOI: 10.1074/jbc.M407558200

Genes

KCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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