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Article

The mammalian complement system as an epitome of host–pathogen genetic conflicts

2 Feb 2016

Abstract excerpt

The complement system is an innate immunity effector mechanism; its action is antagonized by a wide array of pathogens and complement evasion determines the virulence of several infections. We investigated the evolutionary history of the complement system and of bacterial-encoded complement-interacting proteins. Complement components targeted by several pathogens evolved under strong selective pressure in...

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PMID: 26836579
DOI: 10.1111/mec.13558

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