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Complement Regulation by Kaposi's Sarcoma-Associated Herpesvirus ORF4 Protein

11 Dec 2002

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with three types of human tumor: Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma. The virus encodes a number of proteins that participate in disrupting the immune response, one of which was predicted by sequence analysis to be encoded by open reading frame 4 (ORF4). The predicted ORF4 protein shares homology with...

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PMID: 12477863
DOI: 10.1128/jvi.77.1.592-599.2003

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