Article
Identification of complement regulatory domains in vaccinia virus complement control protein.
Journal of virology - 1 Oct 2005
Mullick Jayati, Bernet John, Panse Yogesh, Hallihosur Sharanabasava, Singh Akhilesh K, Sahu Arvind
Abstract excerpt
Vaccinia virus encodes a homolog of the human complement regulators named vaccinia virus complement control protein (VCP). It is composed of four contiguous complement control protein (CCP) domains. Previously, VCP has been shown to bind to C3b and C4b and to inactivate the classical and alternative pathway C3 convertases by accelerating the decay of the classical pathway C3 convertase and (to a limited extent)...
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