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Article

Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes.

The Journal of biological chemistry - 22 Oct 2004

Xia Xuefeng, Roundtree Marlon, Merikhi Afkhamossadat, Lu Xiaohui, Shentu Shujun, Lesage Gene

Abstract excerpt

To attenuate injury during cholestasis, adaptive changes in bile acid transporter expression in the liver provide alternative bile acid excretory pathways. Apical sodium-dependent bile acid transporter (ASBT) (SLC10A2), only expressed in the liver on the cholangiocyte apical membrane, is rapidly regulated in response to inflammation and bile acids. Here, we studied the mechanisms controlling ASBT protein levels...

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Identifiers

PMID: 15304498
DOI: 10.1074/jbc.M400969200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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