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Article

Short-chain ubiquitination is associated with the degradation rate of a cell-surface-resident bile salt export pump (BSEP/ABCB11).

Molecular pharmacology - 1 Jan 2009

Hayashi Hisamitsu, Sugiyama Yuichi

Abstract excerpt

The reduced expression of the bile salt export pump (BSEP/ABCB11) at the canalicular membrane is associated with cholestasis-induced hepatotoxicity due to the accumulation of bile acids in hepatocytes. We demonstrated previously that 4-phenylbutyrate (4PBA) treatment, a U.S. Food and Drug Adminis...

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Source

Identifiers

PMID: 18829893
DOI: 10.1124/mol.108.049288

Genes

ABCB11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18829893-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Short-chain ubiquitination is associated with the degradation rate of a cell-surface-resident bile salt export pump (BSEP/ABCB11).PMID 18829893Read ↗

Differential roles of ubiquitination in the degradation mechanism of cell surface-resident bile salt export pump and multidrug resistance-associated protein 2.Semantic proximity Read ↗

Ursodeoxycholic acid stabilizes the bile salt export pump in the apical membrane in MDCK II cells.Semantic proximity Read ↗

Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells.Semantic proximity Read ↗

Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes.Semantic proximity Read ↗

Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel.Semantic proximity Read ↗

4-phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps.Semantic proximity Read ↗

Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases.Semantic proximity Read ↗

Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells.Semantic proximity Read ↗

Bile salt export pump (BSEP/ABCB11): trafficking and sorting disturbances.Semantic proximity Read ↗

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