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Article

Autophagy induced by exogenous bile acids is therapeutic in a model of α-1-AT deficiency liver disease.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jul 2016

Tang Youcai, Fickert Peter, Trauner Michael, Marcus Nancy, Blomenkamp Keith, Teckman Jeffrey

Abstract excerpt

The bile acid nor-ursodeoxycholic acid (norUDCA) has many biological actions, including antiapoptotic effects. Homozygous PIZZ α-1-antitrypsin (A1AT)-deficient humans are known to be at risk for liver disease, cirrhosis, and liver cancer as a result of the accumulation of the toxic, A1AT mutant Z protein within hepatocytes. This accumulation triggers cell death in the hepatocytes with the largest mutant Z-protein...

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Source

Identifiers

PMID: 27102560
DOI: 10.1152/ajpgi.00143.2015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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