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Article

Use of protein knobs to characterize the position of conserved alpha-subunit regions in lutropin receptor complexes.

The Journal of biological chemistry - 22 Oct 2004

Xing Yongna, Lin Win, Jiang Mei, Cao Donghui, Myers Rebecca V, Bernard Michael P, Moyle William R

Abstract excerpt

Efforts to identify the manner in which human choriogonadotropin (hCG) contacts lutropin receptors (LHR) have been stymied by the complex structure of the hormone and the likelihood that it contacts the receptor at multiple sites. During studies of hCG assembly in mammalian cells, we found that addition of a cysteine to the long disordered beta-subunit COOH terminus (betaCT) enabled it to become cross-linked by a...

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Identifiers

PMID: 15304492
DOI: 10.1074/jbc.M406931200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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