Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelial lipase promotes apolipoprotein AI-mediated cholesterol efflux in THP-1 macrophages.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2009

Qiu Guosong, Hill John S

Abstract excerpt

OBJECTIVE: Endothelial lipase (EL) is expressed by macrophages within atherosclerotic lesions. We investigated the influence of EL expression on cholesterol efflux in macrophages. METHODS AND RESULTS: The present study used lentivirus to introduce either EL shRNA for loss-of-function studies or EL cDNA for gain-of-function studies to investigate the role of EL in apoAI-mediated cholesterol efflux. ApoAI-mediated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein A-I
Share to Atherosclerosis
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Share to Cholesterol

Share to Heparin

Share to Lipase

Share to Monocytes

Source

Identifiers

PMID: 18988890
DOI: 10.1161/ATVBAHA.108.176487

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelial lipase promotes apolipoprotein AI-mediated cholesterol efflux in THP-1 macrophages.PMID 18988890Read ↗

Update on the role of endothelial lipase in high-density lipoprotein metabolism, reverse cholesterol transport, and atherosclerosis.Semantic proximity Read ↗

Effects of nonlipolytic ligand function of endothelial lipase on high density lipoprotein metabolism in vivo.Semantic proximity Read ↗

Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice.Semantic proximity Read ↗

A rare gain of function variant of hepatic lipase attenuates hypercholesterolaemia and atherosclerosis in mice via an LDL receptor-independent mechanism.Semantic proximity Read ↗

Endothelial lipase facilitates low-density lipoprotein (LDL) uptake in LDL receptor deficiency by a heparan sulfate proteoglycan-dependent mechanismSemantic proximity Read ↗

Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism.Semantic proximity Read ↗

Genetic and structure-function studies of missense mutations in human endothelial lipase.Semantic proximity Read ↗

Endothelial lipase is a major determinant of HDL levelSemantic proximity Read ↗

Endothelial lipase is a major determinant of HDL level.Semantic proximity Read ↗

Angiopoietin like protein 3 regulates low-density lipoprotein transport through aortic endothelial cells via endothelial lipaseSemantic proximity Read ↗

Increased Hepatic Expression of Endothelial Lipase Inhibits Cholesterol Diet-Induced Hypercholesterolemia and Atherosclerosis in Transgenic Rabbits.Semantic proximity Read ↗

Secretion and transfer of adipose lipoprotein lipase utilizes neutral sphingomyelinase 2 generated exosomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.