Article
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits.
The Journal of biological chemistry - 22 Oct 2004
Jones Eugenia M C, Roti Roti Elon C, Wang Jinling, Delfosse Samantha A, Robertson Gail A
Abstract excerpt
Previous studies suggest native cardiac IKr channels are composed of alpha subunits encoded solely by the 1a transcript of the ERG1 gene. Using isoform-specific ERG1 antibodies, we have new evidence that subunits encoded by an alternate transcript, ERG1b, are also expressed in rat, canine, and human heart. The ERG1a and -1b subunits associate in vivo where they localize to the T tubules of ventricular myocytes....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.