Article
v-Abl signaling disrupts SOCS-1 function in transformed pre-B cells.
Molecular cell - 13 Aug 2004
Limnander André, Danial Nika N, Rothman Paul B
Abstract excerpt
The v-Abl oncogene activates Jak-Stat signaling during transformation of pre-B cells in mice. Disrupting Jak activation by deleting the Jak binding domain of v-Abl or by expressing a dominant-negative Jak1 decreases v-Abl transformation efficiency. As SOCS-1 is a known potent inhibitor of Jak kinases, the mechanism by which v-Abl bypasses SOCS-1 regulation to constitutively activate Jak kinases was investigated....
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