Article
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.
The EMBO journal - 15 Jan 1999
Nicholson S E, Willson T A, Farley A, Starr R, Zhang J G, Baca M, Alexander W S, Metcalf D, Hilton D J, Nicola N A
Abstract excerpt
SOCS-1 (suppressor of cytokine signaling-1) is a representative of a family of negative regulators of cytokine signaling (SOCS-1 to SOCS-7 and CIS) characterized by a highly conserved C-terminal SOCS box preceded by an SH2 domain. This study comprehensively examined the ability of several SOCS fa...
Topics
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Carrier Proteins
- Cell Differentiation
- Cell Line
- Cytokines
- DNA-Binding Proteins
- Growth Inhibitors
- Interleukin-6
- JNK Mitogen-Activated Protein Kinases
- Leukemia Inhibitory Factor
- Lymphokines
- Mice