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Article

A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box.

The Journal of biological chemistry - 2 Nov 2001

Hanada T, Yoshida T, Kinjyo I, Minoguchi S, Yasukawa H, Kato S, Mimata H, Nomura Y, Seki Y, Kubo M, Yoshimura A

Abstract excerpt

Cytokines exert biological functions by activating Janus tyrosine kinases (JAKs), and JAK inhibitors JAB (also referred to as SOCS1 and SSI1) and CIS3 (SOCS3) play an essential role in the negative regulation of cytokine signaling. We have found that transgenic (Tg) mice expressing a mutant JAB (...

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Source

Identifiers

PMID: 11522790
DOI: 10.1074/jbc.M106139200

Genes

SOCS1
JAK2
SOCS3
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-11522790-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

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Research trail→

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A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box.PMID 11522790Read ↗

v-Abl signaling disrupts SOCS-1 function in transformed pre-B cells.Semantic proximity Read ↗

Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and CancerSemantic proximity Read ↗

Suppressors of Cytokine Signaling (SOCS) Proteins and JAK/STAT PathwaysSemantic proximity Read ↗

The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.Semantic proximity Read ↗

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.Semantic proximity Read ↗

miR-19a: An Effective Regulator of SOCS3 and Enhancer of JAK-STAT SignallingSemantic proximity Read ↗

Negative regulation of cytokine signaling and immune responses by SOCS proteins.Semantic proximity Read ↗

<i>Drosophila</i>SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanismsSemantic proximity Read ↗

SOCS3 Deletion in T Lymphocytes Suppresses Development of Chronic Ocular Inflammation via Upregulation of CTLA-4 and Expansion of Regulatory T CellsSemantic proximity Read ↗

Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor–β1Semantic proximity Read ↗

The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivoSemantic proximity Read ↗

Heterogeneous inducible mammary-specific expression of Jab/SOCS1 in lactating transgenic mice is associated with no obvious phenotype, even at the cellular level.Semantic proximity Read ↗

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