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Article

Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line.

Blood - 15 Mar 2005

Melzner Ingo, Bucur Alexandra Juliana, Brüderlein Silke, Dorsch Karola, Hasel Cornelia, Barth Thomas F E, Leithäuser Frank, Möller Peter

Abstract excerpt

Primary mediastinal B-cell lymphoma (PMBL) is a well-defined subtype of diffuse large B-cell lymphoma. Molecular cytogenetics revealed frequent gains of 9p24. JAK2, mapping in this region, is presently regarded as a candidate oncogene because expression profiling showed high Janus kinase-2 (JAK2) transcript levels and JAK2 was found to be constitutively phosphorylated in mediastinal B-cell lymphomas. We confirm...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, B-Cell

Share to Mediastinal Neoplasms

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Share to STAT5 Transcription Factor

Share to Suppressor of Cytokine Signaling 1 Protein

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Source

Identifiers

PMID: 15572583
DOI: 10.1182/blood-2004-09-3701

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line.PMID 15572583Read ↗

[Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in MedB-1 mediastinal lymphoma line].Semantic proximity Read ↗

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