Article
A requirement for SOCS-1 and SOCS-3 phosphorylation in Bcr-Abl-induced tumorigenesis.
Neoplasia (New York, N.Y.) - 1 Jun 2012
Qiu Xiaoxue, Guo Guijie, Chen Ke, Kashiwada Masaki, Druker Brian J, Rothman Paul B, Chen Ji-Long
Abstract excerpt
Suppressors of cytokine signaling 1 and 3 (SOCS-1 and SOCS-3) are inhibitors of the Janus tyrosine kinase (JAK)/signal transducers and activators of transcription (STAT) pathway and function in a negative feedback loop during cytokine signaling. Abl transformation is associated with constitutive activation of JAK/STAT-dependent signaling. However, the mechanism by which Abl oncoproteins bypass SOCS inhibitory...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.