Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of fibrinogen- and platelet-mediated hemostasis in mouse embryogenesis and reproduction.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2004

Palumbo J S, Zogg M, Talmage K E, Degen J L, Weiler H, Isermann B H

Abstract excerpt

Studies of mice with genetic deficits in specific coagulation factors have shown that many, but not all, components of the hemostatic system serve an essential role in mouse embryogenesis and pregnancy. Although the developmental failures observed in these mice are typically associated with severe hemorrhage, it is uncertain whether the role of coagulation factors in embryogenesis and reproduction is specifically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Diphosphate
Share to Blood Platelets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erythroid-Specific DNA-Binding Factors

Share to Fibrinogen

Share to GTP-Binding Protein alpha Subunits, Gq-G11

Share to Hemostasis

Share to Placenta

Share to Yolk Sac

Source

Identifiers

PMID: 15304043
DOI: 10.1111/j.1538-7836.2004.00788.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of fibrinogen- and platelet-mediated hemostasis in mouse embryogenesis and reproduction.PMID 15304043Read ↗

Genetic interactions between the coagulation and fibrinolytic systems.Semantic proximity Read ↗

Gene targeting of components of the fibrinolytic system.Semantic proximity Read ↗

Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency.Semantic proximity Read ↗

Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation.Semantic proximity Read ↗

Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice.Semantic proximity Read ↗

Special considerations in the evaluation of the hematology and hemostasis of mutant mice.Semantic proximity Read ↗

Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothersSemantic proximity Read ↗

Prothrombin deficiency results in embryonic and neonatal lethality in mice.Semantic proximity Read ↗

Combined tissue factor pathway inhibitor and thrombomodulin deficiency produces an augmented hypercoagulable state with tissue-specific fibrin deposition.Semantic proximity Read ↗

Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice.Semantic proximity Read ↗

Low levels of tissue factor are compatible with development and hemostasis in mice.Semantic proximity Read ↗

Zebrafish: a genetic model for hemostasis and thrombosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.