Article
1,4-Dihydropyridine calcium channel blockers inhibit plasma and LDL oxidation and formation of oxidation-specific epitopes in the arterial wall and prolong survival in stroke-prone spontaneously hypertensive rats.
Stroke - 1 Sept 1999
Napoli C, Salomone S, Godfraind T, Palinski W, Capuzzi D M, Palumbo G, D'Armiento F P, Donzelli R, de Nigris F, Capizzi R L, Mancini M, Gonnella J S, Bianchi A
Abstract excerpt
BACKGROUND AND PURPOSE: Calcium-channel blockers (CCBs) reduce systolic blood pressure and stroke-related mortality in stroke-prone spontaneously hypertensive rats (SPSHR). Brain ischemia is associated with loss of intracellular antioxidants. Increased formation of oxygen radicals and oxidation of LDL may enhance arterial vasoconstriction by various mechanisms. CCBs that also exert antioxidative properties in...
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