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Article

Can we identify genes for susceptibility to diabetic microangiopathies using stroke-prone spontaneously hypertensive rat models?

Medical hypotheses - 1 Apr 2001

Yamagishi S, Takeuchi M, Unoki H

Abstract excerpt

The aortic biochemical properties are reported to be altered in stroke-prone spontaneously hypertensive rats (SHR-SPs) as a result not only of the accelerated accumulation of advanced glycation end products (AGEs) in thoracic aortae but also of primary defects. There is a growing body of evidence that reactive oxygen species (ROS) are involved in the formation of AGEs. We propose here a novel hypothesis that...

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Source

Identifiers

PMID: 11339857
DOI: 10.1054/mehy.2000.1257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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