Vitamin E prevents apoptosis in cortical neurons during hypoxia and oxygen reperfusion.

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Article

Vitamin E prevents apoptosis in cortical neurons during hypoxia and oxygen reperfusion.

Laboratory investigation; a journal of technical methods and pathology - 1 Nov 1998

Tagami M, Yamagata K, Ikeda K, Nara Y, Fujino H, Kubota A, Numano F, Yamori Y

Abstract excerpt

Cerebral ischemia followed by oxygen reperfusion induces apoptosis in hippocampal neurons in stroke-prone spontaneously hypertensive rats (SHRSP) but not in Wistar Kyoto rats (WKY). The overproduction of oxygen-free radicals that occurs in the tissues of SHRSP is implicated in reoxygenation injur...

Topics

Animals
Antioxidants
Apoptosis
Benzoquinones
Cerebral Cortex
Cerebrovascular Disorders
Free Radical Scavengers
Genetic Predisposition to Disease
Hypoxia, Brain
Necrosis
Neurons
Nitric Oxide
Osmolar Concentration
Oxygen
Rats
Rats, Inbred SHR
Rats, Wistar
Reperfusion

Source

Open in PubMed

Identifiers

PMID: 9840616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9840616-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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