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Article

L-chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro.

Virology - 1 Sept 2004

Reinke Ryan A, Lee Deborah J, McDougall Brenda R, King Peter J, Victoria Joseph, Mao Yingqun, Lei Xiangyang, Reinecke Manfred G, Robinson W Edward

Abstract excerpt

The human immunodeficiency virus (HIV) integrase (IN) must covalently join the viral cDNA into a host chromosome for productive HIV infection. l-Chicoric acid (l-CA) enters cells poorly but is a potent inhibitor of IN in vitro. Using quantitative real-time polymerase chain reaction (PCR), l-CA inhibits integration at concentrations from 500 nM to 10 microM but also inhibits entry at concentrations above 1 microM....

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Identifiers

PMID: 15302207
DOI: 10.1016/j.virol.2004.06.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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