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Article

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells.

Science (New York, N.Y.) - 28 Jan 2000

Hazuda D J, Felock P, Witmer M, Wolfe A, Stillmock K, Grobler J A, Espeseth A, Gabryelski L, Schleif W, Blau C, Miller M D

Abstract excerpt

Integrase is essential for human immunodeficiency virus-type 1 (HIV-1) replication; however, potent inhibition of the isolated enzyme in biochemical assays has not readily translated into antiviral activity in a manner consistent with inhibition of integration. In this report, we describe diketo...

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Identifiers

PMID: 10649997
DOI: 10.1126/science.287.5453.646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10649997-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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