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Article

Human immunodeficiency virus integration in a cell-free system

1 Jun 1990

Abstract excerpt

Integration of the viral genome into the nuclear DNA of a host cell plays a pivotal role in the replication of retroviruses. We have developed an in vitro method for studying the biochemistry of human immunodeficiency virus (HIV) integration by using extracts from HIV-infected cells. Analysis of the reaction products showed that HIV integration in vitro accurately reproduces the in vivo process. Integration...

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PMID: 2335814
DOI: 10.1128/jvi.64.6.2711-2715.1990

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