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Article

Entropy-enthalpy compensation in ionic interactions probed in a zinc finger peptide.

Biochemistry - 17 Aug 2004

Blasie Cheryl A, Berg Jeremy M

Abstract excerpt

Zinc(II) and cobalt(II) binding to a series of zinc finger peptides with different charged residue pairs across from one another in a beta-sheet were examined. Previous studies revealed a narrow range of interaction free energies (<0.5 kcal/mol) between these residues. Here, isothermal titration calorimetry studies were performed, revealing a range of over 3 kcal/mol in relative binding enthalpies. Double mutant...

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PMID: 15301557
DOI: 10.1021/bi0363230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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