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Article

Functional Role of Solvent Entropy and Conformational Entropy of Metal Binding in a Dynamically Driven Allosteric System.

Journal of the American Chemical Society - 25 Jul 2018

Capdevila Daiana A, Edmonds Katherine A, Campanello Gregory C, Wu Hongwei, Gonzalez-Gutierrez Giovanni, Giedroc David P

Abstract excerpt

Allostery is a regulatory phenomenon whereby ligand binding to one site influences the binding of the same or a different ligand to another site on a macromolecule. The physical origins of allosteric regulation remain under intense investigation. In general terms, ligand-induced structural changes, perturbations of residue-specific dynamics, and surrounding solvent molecules all potentially contribute to the...

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Identifiers

PMID: 29953213
DOI: 10.1021/jacs.8b02129
PMCID: PMC6425489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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