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Article

Extreme entropy-enthalpy compensation in a drug-resistant variant of HIV-1 protease.

ACS chemical biology - 21 Sept 2012

King Nancy M, Prabu-Jeyabalan Moses, Bandaranayake Rajintha M, Nalam Madhavi N L, Nalivaika Ellen A, Özen Ayşegül, Haliloğlu Türkan, Yilmaz Neşe Kurt, Schiffer Celia A

Abstract excerpt

The development of HIV-1 protease inhibitors has been the historic paradigm of rational structure-based drug design, where structural and thermodynamic analyses have assisted in the discovery of novel inhibitors. While the total enthalpy and entropy change upon binding determine the affinity, often the thermodynamics are considered in terms of inhibitor properties only. In the current study, profound changes are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22712830
DOI: 10.1021/cb300191k
PMCID: PMC3594831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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