Article
Modulation of zinc- and cobalt-binding affinities through changes in the stability of the zinc ribbon protein L36.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry - 1 Mar 2005
Kou Wenpeng, Kolla Harsha S, Ortiz-Acevedo Alfonso, Haines Donovan C, Junker Matthew, Dieckmann Gregg R
Abstract excerpt
Cysteine-rich Zn(II)-binding sites in proteins serve two distinct functions: to template or stabilize specific protein folds, and to facilitate chemical reactions such as alkyl transfers. We are interested how the protein environment controls metal site properties, specifically, how naturally occurring tetrahedral Zn(II) sites are affected by the surrounding protein. We have studied the Co(II)- and Zn(II)-binding...
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