Article

Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population

2004-11-01

Abstract excerpt

Homozygosity for mutations in ABC transporter A1 (ABCA1) causes Tangier disease, a rare HDL-deficiency syndrome. Whether heterozygosity for genetic variation in ABCA1 also contributes to HDL cholesterol (HDL-C) levels in the general population is presently unclear. We determined whether mutations or single-nucleotide polymorphisms (SNPs) in ABCA1 were overrepresented in individuals with the lowest 1% (n = 95) or h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 703563f6-da8b-5b2f-829f-2df9689a9c92
DOI: 10.1172/jci200420361

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general populationDOI 10.1172/jci200420361Read

Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population.Semantic proximity Read

Multiple rare alleles contribute to low plasma levels of HDL cholesterol.Semantic proximity Read

Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels.Semantic proximity Read

Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis.Semantic proximity Read

Do DNA sequence variants in ABCA1 contribute to HDL cholesterol levels in the general population?Semantic proximity Read

Genotypic variation in ATP-binding cassette transporter-1 (ABCA1) as contributors to the high and low high-density lipoprotein-cholesterol (HDL-C) phenotype.Semantic proximity Read

Common variants in the gene encoding ATP-binding cassette transporter 1 in men with low HDL cholesterol levels and coronary heart disease.Semantic proximity Read

Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes.Semantic proximity Read

Common and rare ABCA1 variants affecting plasma HDL cholesterol.Semantic proximity Read

Genetic variation in the ABCA1 gene, HDL cholesterol, and risk of ischemic heart disease in the general population.Semantic proximity Read

Novel rare alleles of ABCA1 are exclusively associated with extreme high-density lipoprotein-cholesterol levels among the Han Chinese.Semantic proximity Read

Familial HDL deficiency due to ABCA1 gene mutations with or without other genetic lipoprotein disorders.Semantic proximity Read