Article
Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels.
Clinical genetics - 1 Mar 2006
Boekholdt S M, Souverein O W, Tanck M W T, Hovingh G K, Kuivenhoven J A, Peters R I G, Jansen H, Schiffers P M H, van der Wall E E, Doevendans P A, Reitsma P H, Zwinderman A H, Kastelein J J P, Jukema J W
Abstract excerpt
It is assumed that the combined effects of multiple common genetic variants explain a large part of variation of high-density lipoprotein cholesterol (HDL-C) plasma levels, but little evidence exists to corroborate this assumption. It was our objective to study the contribution of multiple common genetic variants of HDL-C-related genes to variation of HDL-C plasma levels. A well-characterized cohort of 546...
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