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Article

Genetic determinants of plasma HDL-cholesterol levels in familial hypercholesterolemia.

European journal of human genetics : EJHG - 1 Oct 2005

van Aalst-Cohen Emily S, Jansen Angelique C M, Boekholdt S Matthijs, Tanck Michael W T, Fontecha Marcel R, Cheng Suzanne, Li Jia, Defesche Joep C, Kuivenhoven Jan Albert, Kastelein John J P

Abstract excerpt

The objective of this study was to determine the extent to which common genetic variants can explain the variation of high-density lipoprotein cholesterol (HDL-C) plasma levels in familial hypercholesterolemia (FH). FH is characterized by elevated low-density lipoprotein cholesterol levels and premature cardiovascular disease (CVD). Although low HDL-C levels have been shown to affect the severity of the clinical...

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PMID: 16030523
DOI: 10.1038/sj.ejhg.5201467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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